Diffusive micromixing combined with dynamic in situ laser scattering allows shedding light on lipid nanoparticle precipitation.

ABSTRACT: Pharmaceutical formulations are increasingly based on drug nanoparticles or carrier nanoparticles encapsulating drugs or mRNA molecules. Sizes and monodispersity of the nanoparticles regulate bioavailability, pharmacokinetics and pharmacology. Microfluidic mixers promise unique conditions for their continuous preparation. A novel microfluidic antisolvent precipitation device was realized by two-photon-polymerization with a mixing channel in which the organic phase formed a sheet with a homogeneous thickness of down to 7 μm completely wrapped in the aqueous phase. Homogeneous diffusion through the sheet accelerates mixing. Optical access was implemented to allow in-situ dynamic light scattering. By centering the thin sheet in the microchannel cross-section, two important requirements are me

SUBMITTER: Taiedinejad E 

PROVIDER: S-EPMC11487189 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature