Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice.

ABSTRACT: Osteopetrosis is an inherited metabolic disease, characterized by increased bone density and narrow marrow cavity. Patients with severe osteopetrosis exhibit abnormal bone brittleness, anemia, and infection complications, which commonly cause death within the first decade of life. Pathologically, osteopetrosis impairs not only the skeletal system, but also the hemopoietic and immune systems during development, while the underlying osteoimmunological mechanisms remain unclear. Osteoclastic mutations are regarded as the major causes of osteopetrosis, while osteoclast non-autonomous theories have been proposed in recent years with unclear underlying mechanisms. Retinoic acid (RA), the metabolite of Vitamin A, is an essential requirement for skeletal and hematopoietic development, through the

SUBMITTER: Sun S 

PROVIDER: S-EPMC11487257 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature