Hemopexin alleviates sterile inflammation in ischemia-reperfusion-induced lung injury.

ABSTRACT:

Introduction

Pulmonary ischemia-reperfusion (IR) injury (IRI) plays a significant role in various lung disorders and is a key factor in the development of primary graft dysfunction following lung transplantation. Hemopexin (Hx) is the major serum scavenger protein for heme, which is a prooxidant and pro-inflammatory compound. In the current study, we hypothesized that Hx could confer beneficial effects in sterile inflammation induced by IR-mediated lung injury.

Methods

To examine this hypothesis, we administered Hx in an experimental mouse model of unilateral lung IRI.

Results

Our results demonstrate that treatment with Hx alleviated histopathological signs of inflammation in ischemic lungs, as evidenced by a reduction in the number of infiltrating neutrophils and dec

SUBMITTER: Nakagiri T 

PROVIDER: S-EPMC11487521 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature