Structural Transformations of Metal-Organic Cages through Tetrazine-Alkene Reactivity.

ABSTRACT: The assembly of metal-organic cages is governed by metal ion coordination preferences and the geometries of the typically rigid and planar precursor ligands. Pd_nL_2n cages are among the most structurally diverse, with subtle differences in the metal-ligand coordination vectors resulting in drastically different assemblies, however almost all rely on rigid aromatic linkers to avoid the formation of intractable mixtures. Here we exploit the inverse electron-demand Diels-Alder (IEDDA) reaction between tetrazine linker groups and alkene reagents to trigger structural changes induced by post-assembly modification. The structure of the 1,4-dihydropyridazine produced by IEDDA (often an afterthought in click chemistry) is crucial; its two sp³ centers i

SUBMITTER: Black MR 

PROVIDER: S-EPMC11487605 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature