Optimizing Solid Microneedle Design: A Comprehensive ML-Augmented DOE Approach.

ABSTRACT: Microneedles (MNs), that is, a matrix of micrometer-scale needles, have diverse applications in drug delivery, skincare therapy, and health monitoring. MNs offer a minimally invasive alternative to hypodermic needles, characterized by rapid and painless procedures, cost-effective fabrication methods, and reduced tissue damage. This study explores four MN designs, cone-shaped, tapered cone-shaped, pyramidal with a square base, and pyramidal with a triangular-shaped base, and their optimization based on predefined criteria. The workflow encompasses three loading conditions: compressive load during insertion, critical buckling load, and bending loading resulting from incorrect insertion. Geometric parameters such as base radius/width, tip radius/width, height, and tapered angle tip influence

SUBMITTER: Abdullah AC 

PROVIDER: S-EPMC11487659 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature