Activatable Multiplexed ¹⁹F NMR Probes for Dynamic Monitoring of Biomarkers Associated with Cellular Senescence.

ABSTRACT: Simultaneous detection of multiple biomarkers is crucial to achieve specific and dynamic analysis of cellular senescence, given its intrinsic high heterogeneity. Current approaches for senescence detection largely rely on fluorescence imaging, but fluorescent probes inevitably suffer from issues including autofluorescence and spectral overlap when being applied for the simultaneous detection of multiple biomarkers. Herein, we report an alternative strategy and design activatable multiplexed senoprobes based on ¹⁹F NMR for dynamic monitoring of cellular senescence. Differing from previous approaches, our strategy has two unique advantages. First, this strategy utilizes the changes in the ¹⁹F chemical shift as the signal output, which features by its fingerprint and qua

SUBMITTER: Wang J 

PROVIDER: S-EPMC11487673 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature