Diagnostic Utility of SARS-CoV-2 Nucleocapsid Antigenemia: A Meta-analysis.

ABSTRACT:

Background

Studies of the diagnostic performance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid antigen in blood (antigenemia) have reached variable conclusions. The potential utility of antigenemia measurements as a clinical diagnostic test needs clarification.

Methods

We performed a systematic review of Pubmed, Embase, and Scopus through July 15, 2023, and requested source data from corresponding authors.

Results

Summary sensitivity from 16 studies (4543 cases) sampled at ≤14 days of symptoms was 0.83 (0.75-0.89), and specificity was 0.98 (0.87-1.00) from 6 studies (792 reverse transcription polymerase chain reaction-negative controls). Summary sensitivity and specificity for paired respiratory specimens with cycle threshold values ≤33

SUBMITTER: Damhorst GL 

PROVIDER: S-EPMC11487748 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature