Association between exposure to proton pump inhibitors and delirium: a descriptive and disproportionality analysis of VigiBase.

ABSTRACT:

Objectives

Proton pump inhibitor (PPI) exposure can lead to hyponatraemia, which is a common cause of delirium. An association between PPI exposure and delirium without hyponatraemia has been suggested in the literature. We aimed to describe the association between reports of delirium and PPI exposure and to assess the association between PPI and delirium with and without hyponatraemia.

Design

A descriptive and disproportionality analysis of claims data.

Setting

World pharmacovigilance database VigiBase between 1 January 1991 and 9 February 2022.

Primary and secondary outcome measures

In the first part, we described reports of delirium for which involvement of a PPI or interactions of PPIs with other drugs were suspected. In the second part, delirium cases and

SUBMITTER: Decros A 

PROVIDER: S-EPMC11487780 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature