Sex differences in mortality among patients with lupus nephritis.

ABSTRACT:

Objective

To evaluate the prognostic importance of sex in lupus nephritis (LN).

Methods

A retrospective cohort of 1048 biopsy-confirmed LN patients, diagnosed between January 1, 1996, and December 31, 2018, was analyzed. Demographics, clinical characteristics, laboratory findings, and renal pathology were assessed. The primary outcome was mortality, and the secondary outcomes included doubling of serum creatinine and end-stage renal disease (ESRD). Sex-associated risks were evaluated using Cox regression models.

Results

Among the1048 patients, 178 (17%) were male and 870 (83%) were female. Male patients exhibited more aggressive features: higher blood pressure, earlier disease onset, and elevated levels of serum creatinine (Scr), uric acid, blood urea nitrogen. Intrig

SUBMITTER: Xiang W 

PROVIDER: S-EPMC11487887 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature