Naturalistic psychedelic therapy: The role of relaxation and subjective drug effects in antidepressant response.

ABSTRACT:

Background

Psychedelic-assisted therapy (PAT) is permitted in Switzerland under its limited medical use program. Data from patients in this program represent a unique opportunity to analyze the real-world practice of PAT.

Aims

This study compared the subjective effects of lysergic acid diethylamide (LSD) and psilocybin between patients undergoing PAT and healthy volunteers. For the patients, it also investigated the relationship between antidepressant effects and six measures of acute drug effects.

Methods

We compared data on acute psychedelic drug effects between 28 PAT patients with data from 28 healthy participants who participated in a randomized, double-blind crossover trial. All participants received varying doses of psilocybin and LSD. Subjective effects were a

SUBMITTER: Calder AE 

PROVIDER: S-EPMC11487903 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature