Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [¹⁸F]FE-PE2I PET: independent validation with new insights.

ABSTRACT: [¹⁸F]FE-PE2I PET is a promising alternative to single positron emission computed tomography-based dopamine transporter (DAT) imaging in Parkinson's disease. While the excellent discriminative power of [¹⁸F]FE-PE2I PET has been established, so far only one study has reported meaningful associations between motor severity scores and DAT availability. In this study, we use high-resolution (∼3 mm isotropic) PET to provide an independent validation for the clinical correlates of [¹⁸F]FE-PE2I imaging in separate cross-sectional (28 participants with Parkinson's disease, Hoehn-Yahr: 2 and 14 healthy individuals) and longitudinal (initial results from 6 participants with Parkinson's disease with 2-year follow-up) cohorts. In the cross-sectional cohort, DAT availabi

SUBMITTER: Honhar P 

PROVIDER: S-EPMC11487911 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature