Sex Differences in Human Brain Structure at Birth.

ABSTRACT:

Background

Sex differences in human brain anatomy have been well-documented, though remain significantly underexplored during early development. The neonatal period is a critical stage for brain development and can provide key insights into the role that prenatal and early postnatal factors play in shaping sex differences in the brain.

Methods

Here, we assessed on-average sex differences in global and regional brain volumes in 514 newborns aged 0-28 days (236 birth-assigned females and 278 birth-assigned males) using data from the developing Human Connectome Project. We also assessed sex-by-age interactions to investigate sex differences in early postnatal brain development.

Results

On average, males had significantly larger intracranial and total brain volumes, even

SUBMITTER: Khan YT 

PROVIDER: S-EPMC11488075 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature