Gene expression profile analysis of severe influenza-based modulation of idiopathic pulmonary fibrosis.

ABSTRACT:

Background

It is known severe influenza infections and idiopathic pulmonary fibrosis (IPF) disease might stimulate each other. Till now, no associated mechanism has been reported.

Method

We collected the genetic pattern of expression of severe influenza (GSE111368) and IPF (GSE70866) from the Gene Expression Omnibus (GEO) database. Common differentially expressed genes (C-DEGs) were identified from the two datasets, and using this data, we conducted three forms of analyses, functional annotation, protein-protein interaction (PPI) network and module construction, and hub gene identification and co-expression analysis.

Results

In all, 174 C-DEGs were selected for additional analyses. Based on our functional analysis, these C-DEGs mediated inflammatory response and cell

SUBMITTER: Kong J 

PROVIDER: S-EPMC11488079 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature