Effectiveness and efficiency of immunisation strategies to prevent RSV among infants and older adults in Germany: a modelling study.

ABSTRACT:

Background

Recently, several novel RSV immunisation products that protect infants and older adults against RSV disease have been licensed in Europe. We estimated the effectiveness and efficiency of introducing these RSV immunisation strategies in Germany.

Methods

We used a Bayesian framework to fit a deterministic age-structured dynamic transmission model of RSV to sentinel surveillance and RSV-specific hospitalisation data in Germany from 2015 to 2019. The calibrated model was used to evaluate different RSV intervention strategies over 5 years: long-acting, single-dose monoclonal antibodies (mAbs) in high-risk infants aged 1-5 months; long-acting mAbs in all infants aged 1-5 months; seasonal vaccination of pregnant women and one-time seasonal vaccination of older adults (75

SUBMITTER: Krauer F 

PROVIDER: S-EPMC11488180 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature