Exploring genetic determinants of antimicrobial resistance in Brucella melitensis strains of human and animal origin from India.

ABSTRACT:

Introduction

Antimicrobial resistance (AMR) in Brucella melitensis, the causative agent of brucellosis, is of growing concern, particularly in low and middle-income countries. This study aimed to explore the genetic basis of AMR in B. melitensis strains from India.

Methods

Twenty-four isolates from humans and animals were subjected to antimicrobial susceptibility testing and whole-genome sequencing.

Results

Resistance to doxycycline (20.80%), ciprofloxacin (16.67%), cotrimoxazole (4.17%), and rifampicin (16.67%) was observed. Genome analysis revealed efflux-related genes like mprF, bepG, bepF, bepC, bepE, and bepD across all isolates, however, classical AMR genes were not detected. Mutations in key AMR-associated

SUBMITTER: Ayoub H 

PROVIDER: S-EPMC11488214 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature