AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off.

ABSTRACT: Translation, a fundamental process regulating cellular growth and proliferation, relies on functional ribosomes. As sessile organisms, plants have evolved adaptive strategies to maintain a delicate balance between growth and stress response. But the underlying mechanisms, particularly on the translational level, remain less understood. In this study, we revealed the mechanisms of AtPRMT3-RPS2B in orchestrating ribosome assembly and managing translational regulation. Through a forward genetic screen, we identified PDCD2-D1 as a suppressor gene restoring abnormal development and ribosome biogenesis in atprmt3-2 mutants. Our findings confirmed that PDCD2 interacts with AtPRMT3-RPS2B, and facilitates pre-ribosome transport through nuclear pore complex, finally ensuring normal ribosome translat

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11488217 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature