Growth differentiation factor 11 alleviates oxidative stress-induced senescence of endothelial progenitor cells via activating autophagy.

ABSTRACT:

Background

Stem cell transplantation has been regarded as a promising therapeutic strategy for myocardial regeneration after myocardial infarction (MI). However, the survival and differentiation of the transplanted stem cells in the hostile ischaemic and inflammatory microenvironment are poor. Recent studies have focused on enhancing the survival and differentiation of the stem cells, while strategies to suppress the senescence of the transplanted stem cells is unknown. Therefore, we investigated the effect of growth differentiation factor 11 (GDF11) on attenuating oxidative stress-induced senescence in the engrafted endothelial progenitor cells (EPCs).

Methods

Rat models of oxidative stress were established by hydrogen peroxide conditioning. Oxidative stress-induced senesce

SUBMITTER: Tao P 

PROVIDER: S-EPMC11488219 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature