Comparative study of pathogen detection methods for central nervous system infections: laboratory testing of tuberculous meningitis.

ABSTRACT:

Background

Tuberculous meningitis (TBM) is a severe central nervous system (CNS) infection with a challenging diagnosis due to inadequate detection methods. This study evaluated current clinical detection methods and their applicability.

Methods

A cohort of 514 CNS infection patients from 2018 to 2020 was studied. Data on general demographics, Cerebrospinal Fluid (CSF) analysis, epidemiology, and clinical outcomes were collected. TBM patients were identified, and the sensitivities of mmetagenomic next-generation sequencing (NGS), GeneXpert, and microbial culture were compared. Kappa statistic assessed the consistency between methods.

Results

Among the patients involved, TBM (29%) and neurosyphilis (25%) were the two most prevalent CNS infections. CSF analysis indicate

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11488244 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature