Autophagy is required for mammary tumor recurrence by promoting dormant tumor cell survival following therapy.

ABSTRACT:

Background

Mortality from breast cancer is principally due to tumor recurrence. Recurrent breast cancers arise from the pool of residual tumor cells, termed minimal residual disease, that survive treatment and may exist in a dormant state for 20 years or more following treatment of the primary tumor. As recurrent breast cancer is typically incurable, understanding the mechanisms underlying dormant tumor cell survival is a critical priority in breast cancer research. The importance of this goal is further underscored by emerging evidence suggesting that targeting dormant residual tumor cells in early-stage breast cancer patients may be a means to prevent tumor recurrence and its associated mortality. In this regard, the role of autophagy in dormant tumor cell survival and recurrence

SUBMITTER: Dwyer S 

PROVIDER: S-EPMC11488247 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature