Synergistic effects of rivaroxaban and hypothermia or acidosis on coagulation initiation measured with ROTEM^®: a prospective observational study.

ABSTRACT:

Background

Hypothermia and acidosis individually inhibit haemostasis. We designed this study with the aim to investigate whether rivaroxaban combined with hypothermia or acidosis exhibit synergistic inhibitory effects on haemostasis using ROTEM^®.

Methods

Patients with a clinical indication to start rivaroxaban treatment were prospectively included. Blood samples were collected before initiation of treatment and the day after. All blood samples were in vitro modified with respect to temperature (incubated and analysed at 28, 33, 37 and 40 degrees Celsius (°C)) and pH (6.8, 7.0, 7.2 and 7.4). The temperature and acidosis effects on the ROTEM EXTEM variables clotting time (CT), clot formation time (CFT) and alpha-angle (AA) were measured along with the individual eff

SUBMITTER: Sunnersjo L 

PROVIDER: S-EPMC11488277 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature