Identification of nicotinamide N-methyltransferase as a promising therapeutic target for sarcopenia.

ABSTRACT: Sarcopenia is a significant geriatric syndrome that involves the loss of skeletal muscle mass and strength. Due to its substantial endocrine role, the metabolic microenvironment of skeletal muscle undergoes changes with age. Examining the pathogenesis of sarcopenia through focusing on metabolic dysregulation could offer insights for developing more effective intervention strategies. In this study, we analyzed the transcriptomics data to identify specific genes involved in the regulation of metabolism in skeletal muscle during the development of sarcopenia. Three machine learning algorithms were employed to screen key target genes exhibiting strong correlations with metabolism, which were further validated using RNA-sequencing data and publicly accessible datasets. Among them, the metabolic

SUBMITTER: Liang R 

PROVIDER: S-EPMC11488295 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature