Sevoflurane-induced overexpression of extrasynaptic α5-GABA_AR via the RhoA/ROCK2 pathway impairs cognitive function in aged mice.

ABSTRACT: Perioperative neurocognitive disorder (PND) is a serious neurologic complication in aged patients and might be associated with sevoflurane exposure. However, the specific pathogenesis is still unclear. The distribution of α5-GABA_AR, a γ-aminobutyric acid type A receptor (GABA_AR) subtype, at extrasynaptic sites is influenced by the anchor protein radixin, whose phosphorylation is regulated via the RhoA/ROCK2 signaling pathway and plays a crucial role in cognition. However, whether sevoflurane affects the ability of radixin phosphorylation to alter extrasynaptic receptor expression is unknown. Aged mice were exposed to sevoflurane to induce cognitive impairment. Both total proteins and membrane proteins were extracted for analysis. Cognitive function was evaluated using

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11488297 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature