Effect of polygenic scores of telomere length alleles on telomere length in newborns and parents.

ABSTRACT: In adults, polygenic scores (PGSs) of telomere length (TL) alleles explain about 4.5% of the variance in TL, as measured by quantitative polymerase chain reaction (qPCR). Yet, these PGSs strongly infer a causal role of telomeres in aging-related diseases. To better understand the determinants of TL through the lifespan, it is essential to examine to what extent these PGSs explain TL in newborns. This study investigates the effect of PGSs on TL in both newborns and their parents, with TL measured by Southern blotting and expressed in base-pairs (bp). Additionally, the study explores the impact of PGSs related to transmitted or non-transmitted alleles on TL in newborns. For parents and newborns, the PGS effects on TL were 172 bp (p =  2.03 × 10^-15) and 161 bp (p =  3.06 × 10^-

SUBMITTER: Lee Y 

PROVIDER: S-EPMC11488311 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature