Pathophysiological processes underlying hidden hearing loss revealed in Kcnt1/2 double knockout mice.

ABSTRACT: Presbycusis is a prevalent condition in older adults characterized by the progressive loss of hearing due to age-related changes in the cochlea, the auditory portion of the inner ear. Many adults also struggle with understanding speech in noise despite having normal auditory thresholds, a condition termed "hidden" hearing loss because it evades standard audiological assessments. Examination of animal models and postmortem human tissue suggests that hidden hearing loss is also associated with age-related changes in the cochlea and may, therefore, precede overt age-related hearing loss. Nevertheless, the pathological mechanisms underlying hidden hearing loss are not understood, which hinders the development of diagnostic biomarkers and effective treatments for age-related hearing loss. To fi

SUBMITTER: Schubert NMA 

PROVIDER: S-EPMC11488318 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature