Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart.

ABSTRACT: The aging heart is characterized by a number of structural changes leading to ventricular stiffness, impaired resistance to stress and increased risk of developing heart failure (HF). Genetic or pharmacological removal of senescent cells has recently demonstrated the possibility to relieve some cardiac aging features such as hypertrophy and fibrosis. However, the contribution of the different cell types in cardiac aging remains fragmentary due to a lack of cell-specific markers. Cardiomyocytes undergo post-mitotic senescence in response to telomere damage, characterized by persistent DNA damage response and expression of the classical senescence markers p21 and p16, which are shared by many other cell types. In the present study, we used transcriptomic approaches to discover new markers sp

SUBMITTER: Maggiorani D 

PROVIDER: S-EPMC11488343 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature