The CD163/TWEAK/Fn14 axis: A potential therapeutic target for alleviating inflammatory bone loss.

ABSTRACT:

Objective

Osteoclast (OC) over-activation is an important cause of bone loss that is strongly correlated with inflammation. Although the CD163/TWEAK/Fn14 axis has been implicated in several inflammatory pathologies, its contributions to inflammatory bone loss remain poorly understood. This study aimed to evaluate the interaction of the CD163/TWEAK/Fn14 axis with OC in inflammatory bone loss.

Methods

To assess the role of CD163 in bone homeostasis, we characterized the bone phenotypes of CD163-deficient mice and their wild-type littermates. CD163 and TWEAK levels were evaluated in the bone marrow of mice with LPS-induced bone loss and individuals with rheumatoid arthritis (RA). Bone mass changes were assessed using uCT and histology following supplementation with recombinant

SUBMITTER: Qian JK 

PROVIDER: S-EPMC11488420 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature