Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan.

ABSTRACT:

Introduction

Identification of neural markers associated with risk for manic symptoms is an important challenge for neuropsychiatric research. Previous work has highlighted the association between predisposition for mania/hypomania and elevated reward sensitivity. Elevated activity in the left ventrolateral prefrontal cortex (L vlPFC) during reward expectancy (RE) is associated with measures predictive of risk for manic/hypomanic symptoms. However, no studies have examined this relationship longitudinally. The goal of this study was to identify a neural marker associated with longitudinal risk for manic/hypomanic symptoms.

Methods

We used a card guessing functional magnetic resonance imaging (fMRI) paradigm to examine RE-related L vlPFC activity. One hundred and three young

SUBMITTER: Edmiston EK 

PROVIDER: S-EPMC11488591 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature