Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain.

ABSTRACT:

Aim

Pain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single-nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) A¹¹⁸G (rs1799971) and catechol-O-methyltransferase (COMT) val¹⁵⁸met (rs4680), we investigated how the two pain genes affect pain processing.

Method

We integrated a genetic approach with functional neuroimaging. We extracted genomic DNA information from saliva samples to genotype the SNP of OPRM1 and COMT. We used a percept-related model, in which two different levels of perceived pain intensities ("low pain: mildly painful" vs "high pain: severely painful

SUBMITTER: Cheong Y 

PROVIDER: S-EPMC11488594 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature