A sensory signature of unaffected biological parents predicts the risk of autism in their offspring.

ABSTRACT:

Aim

Despite the emphasis on sensory dysfunction phenotypes in the revised diagnostic criteria for autism spectrum disorder (ASD), there has been limited research, particularly in the field of neurobiology, investigating the concordance in sensory features between individuals with ASD and their genetic relatives. Therefore, our objective was to examine whether neurobehavioral sensory patterns could serve as endophenotypic markers for ASD.

Methods

We combined questionnaire- and lab-based sensory evaluations with sensory fMRI measures to examine the patterns of sensory responsivity in 30 clinically diagnosed with ASD, 26 matched controls (CON), and 48 biological parents for both groups (27 parents of individuals with ASD [P-ASD] and 21 for individuals with CON [P-CON]).

Resu

SUBMITTER: Chen C 

PROVIDER: S-EPMC11488609 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature