Plasma biomarkers for predicting the development of dementia in a community-dwelling older Japanese population.

ABSTRACT:

Aim

To assess the association between plasma amyloid β (Aβ) 42/40, phosphorylated tau (p-τ)181, glial fibrillary acidic protein (GFAP), or neurofilament light chain (NfL) and the risk of dementia and to determine whether these plasma biomarkers could improve the ability to predict incident dementia in a general older population.

Methods

A total of 1346 Japanese community-dwelling individuals aged ≥65 years without dementia were followed prospectively for 5.0 years. Plasma biomarkers were quantified using a Simoa HD-X analyzer. A Cox proportional hazards model was used to estimate the hazard ratios of each plasma biomarker level for the risk of dementia.

Results

During the follow-up, 151 participants developed dementia, of whom 108 had Alzheimer disease (AD) and 43 non

SUBMITTER: Ohara T 

PROVIDER: S-EPMC11488610 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature