Gray matter reserve determines glymphatic system function in young-onset Alzheimer's disease: Evidenced by DTI-ALPS and compared with age-matched controls.

ABSTRACT:

Background

The diffusion tensor imaging analysis along the perivascular space (ALPS)-index can be used to model the glymphatic system in vivo.

Aim

This study explores putative mechanisms between prediction of ALPS-index and cognitive outcomes in young-onset Alzheimer's disease (YOAD) and age-matched controls (CTLs) and analyzes whether the link was mediated by the integrity of ALPS-index-anchored cerebral gray matter (GM).

Methods

We enrolled 130 patients with YOAD and 137 CTLs. All participants underwent three-dimensional T₁ -weighted MRI, diffusion tensor imaging and cognitive tests. We constructed GM regions correlated with the ALPS-index in the YOAD and CTL groups. For the GM regions significantly correlated with the ALPS-index and cognitive measures, w

SUBMITTER: Chang HI 

PROVIDER: S-EPMC11488612 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature