Differential longitudinal changes of hippocampal subfields in patients with anorexia nervosa.

ABSTRACT:

Background

Anorexia nervosa (AN) is a mental disorder characterized by dietary restriction, fear of gaining weight, and distorted body image. Recent studies indicate that the hippocampus, crucial for learning and memory, may be affected in AN, yet subfield-specific effects remain unclear. We investigated hippocampal subfield alterations in acute AN, changes following weight restoration, and their associations with leptin levels.

Methods

T1-weighted magnetic resonance imaging scans were processed using FreeSurfer. We compared 22 left and right hemispheric hippocampal subfield volumes cross-sectionally and longitudinally in females with acute AN (n = 165 at baseline, n = 110 after partial weight restoration), healthy female controls (HCs; n = 271), and females after long-term

SUBMITTER: Bahnsen K 

PROVIDER: S-EPMC11488614 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature