A circuit-based approach to modulate hypersexuality in Parkinson's disease.

ABSTRACT:

Aim

Impulse-control disorder is a common neuropsychiatric complication in Parkinson's disease (PD) under dopamine replacement therapy. Prior studies tested the balance between enhanced desire towards reward and cognitive control deficits, hypothesized to be biased towards the former in impulse control disorders. We provide evidence for this hypothesis by measuring behavioral and neural patterns behind the influence of sexual desire over response inhibition and tools towards functional restoration using repetitive transcranial stimulation in patients with hypersexuality as predominant impulsive disorder.

Methods

The effect of sexual cues on inhibition was measured with a novel erotic stop-signal task under on and off dopaminergic medication. Task-related functional and anatom

SUBMITTER: Mata-Marin D 

PROVIDER: S-EPMC11488615 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature