Habenular volume changes after venlafaxine treatment in patients with major depression.

ABSTRACT:

Background

Habenula, a hub brain region controlling monoaminergic brain center, has been implicated in major depressive disorder (MDD) and as a possible target of antidepressant response. Nevertheless, the effect of antidepressant drug treatment on habenular volumes remains unknown. The objective of the present research was to study habenular volume change after antidepressant treatment in patients with MDD, and assess whether it is associated with clinical improvement.

Methods

Fifty patients with a current major depressive episode (MDE) in the context of MDD, and antidepressant-free for at least 1 month, were assessed for habenula volume (3T MRI with manual segmentation) before and after a 3 months sequence of venlafaxine antidepressant treatment.

Results

A 2.3% sign

SUBMITTER: Etienne J 

PROVIDER: S-EPMC11488621 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature