Does short-term antipsychotic discontinuation of up to 3 weeks worsen symptoms in acute schizophrenia? A pooled analysis of placebo washout data.

ABSTRACT:

Aim

This study aimed to examine symptom changes during short-term discontinuation of antipsychotics up to 3 weeks including the placebo washout phase in acute schizophrenia.

Methods

The data from three double-blind, randomized, controlled trials comparing lurasidone versus placebo in patients with acute exacerbation of schizophrenia were analyzed. Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS) total and the Clinical Global Impression-Severity scale (CGI-S) scores. The scores before and after the antipsychotic discontinuation phase were compared, and factors associated with score changes were explored.

Results

Among 2154 patients participating in the trials, 600 who received antipsychotic monotherapy and completed the antipsychotic

SUBMITTER: Takeuchi H 

PROVIDER: S-EPMC11488629 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature