Repetitive deep TMS in alcohol dependent patients halts progression of white matter changes in early abstinence.

ABSTRACT:

Aim

Alcohol use disorder (AUD) is the most prevalent form of addiction, with a great burden on society and limited treatment options. A recent clinical trial reported significant clinical benefits of deep transcranial magnetic stimulations (Deep TMS) targeting midline frontocortical areas. However, the underlying biological substrate remained elusive. Here, we report the effect of Deep TMS on the microstructure of white matter.

Methods

A total of 37 (14 females) AUD treatment-seeking patients were randomized to sham or active Deep TMS. Twenty (six females) age-matched healthy controls were included. White matter integrity was evaluated by fractional anisotropy (FA). Secondary measures included brain functional connectivity and self-reports of craving and drinking units in th

SUBMITTER: Selim MK 

PROVIDER: S-EPMC11488632 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature