Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network.

ABSTRACT:

Aim

While conservatism bias refers to the human need for more evidence for decision-making than rational thinking expects, the jumping to conclusions (JTC) bias refers to the need for less evidence among individuals with schizophrenia/delusion compared to healthy people. Although the hippocampus-midbrain-striatal aberrant salience system and the salience, default mode (DMN), and frontoparietal networks ("triple networks") are implicated in delusion/schizophrenia pathophysiology, the associations between conservatism/JTC and these systems/networks are unclear.

Methods

Thirty-seven patients with schizophrenia and 33 healthy controls performed the beads task, with large and small numbers of bead draws to decision (DTD) indicating conservatism and JTC, respectively. We performed

SUBMITTER: Miyata J 

PROVIDER: S-EPMC11488637 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature