Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study.

ABSTRACT:

Aim

To investigate the association of white matter lesions volume (WMLV) levels with dementia risk and the association between dementia risk and the combined measures of WMLV and either total brain atrophy or dementia-related gray matter atrophy in a general older population.

Methods

One thousand one hundred fifty-eight Japanese dementia-free community-residents aged ≥65 years who underwent brain magnetic resonance imaging were followed for 5.0 years. WMLV were segmented using the Lesion Segmentation Toolbox. Total brain volume (TBV) and regional gray matter volume were estimated by voxel-based morphometry. The WMLV-to-intracranial brain volume ratio (WMLV/ICV) was calculated, and its association with dementia risk was estimated using Cox proportional hazard models. Total br

SUBMITTER: Nakazawa T 

PROVIDER: S-EPMC11488640 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature