Nivolumab+AVD in Advanced-Stage Classic Hodgkin's Lymphoma.

ABSTRACT:

Background

Incorporating brentuximab vedotin into the treatment of advanced-stage classic Hodgkin's lymphoma improves outcomes in adult and pediatric patients. However, brentuximab vedotin increases the toxic effects of treatment in adults, more than half of pediatric patients who receive the drug undergo consolidative radiation, and relapse remains a challenge. Programmed death 1 blockade is effective in Hodgkin's lymphoma, including in preliminary studies involving previously untreated patients.

Methods

We conducted a phase 3, multicenter, open-label, randomized trial involving patients at least 12 years of age with stage III or IV newly diagnosed Hodgkin's lymphoma. Patients were randomly assigned to receive brentuximab vedotin with doxorubicin, vinblastine, and dacarbazi

SUBMITTER: Herrera AF 

PROVIDER: S-EPMC11488644 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature