Green and efficient synthesis of 5-amino-1<i>H</i>-pyrazole-5-carbonitriles utilizing novel modified LDH.

ABSTRACT: This research introduced a novel nano catalyst, LDH@PTRMS@DCMBA@CuI, developed from nano copper immobilized on a layered double hydroxide modified with a new type of sulfonamide: N ₁,N ₃-dicarbamimidoylbenzene-1,3-disulfonamide (DCMBA). This catalyst demonstrated significant activity and selectivity in synthesizing 5-amino-1H-pyrazole-5-carbonitrile derivatives. The derivatives were produced via a three-component one-pot reaction combining benzaldehydes, malononitrile, and phenyl hydrazine in H₂O/EtOH solvent at 55 °C. This innovative synthesis strategy offered several advantages, including eco-friendliness, simplicity, stability, mild reaction conditions, easy purification of products, short reaction times (15-27 min), and excel

SUBMITTER: Momeni S 

PROVIDER: S-EPMC11488685 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature