Arterial Lesion Location and Outcomes of Intracranial Atherosclerotic Disease.

ABSTRACT: Intracranial atherosclerosis is a leading cause of stroke with a high recurrence rate despite treatment. Numerous factors are proposed to influence stroke recurrence due to intracranial atherosclerosis including lesion eccentricity, plaque characteristics, and computational fluid dynamic metrics, such as wall shear stress. An overlooked variable that intrinsically relates to intracranial atherosclerosis is the location of the arterial segment where the lesion occurs. Variations in cerebral blood flow, arterial anatomy, and flow dynamics are likely drivers of initial lesion development and thus likely to influence stroke recurrence. To date, treatment trials of intracranial atherosclerosis have not considered arterial segment lesion location as an independent variable, failing to account fo

SUBMITTER: Tariq MB 

PROVIDER: S-EPMC11488790 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature