Isoniazid-associated pellagra during mass scale-up of tuberculosis preventive therapy: a case-control study.

ABSTRACT:

Background

Pellagra is caused by niacin (vitamin B3) deficiency and patients with pellagra present with a characteristic rash. Isoniazid disrupts intracellular niacin synthesis and might induce niacin deficiency. In 2017, Malawi scaled up continuous isoniazid preventive treatment (IPT) for tuberculosis prevention among people living with HIV. In addition, an under-diversified diet based on subsistence maize, as is commonly the case in Malawi, is a risk factor for pellagra. We aimed to investigate whether large-scale isoniazid exposure in Malawi contributed to the cumulative risk for pellagra in a nutritionally vulnerable population.

Methods

We did a matched case-control study to evaluate the association between daily, continuous isoniazid exposure and pellagra. We matched se

SUBMITTER: Nabity SA 

PROVIDER: S-EPMC11488830 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature