Treatment of Membranous Nephropathy in Chinese Patients: Comparison of Rituximab and Intravenous Cyclophosphamide with Steroids.

ABSTRACT:

Introduction

Previous studies have shown that rituximab (RTX) and cyclic oral corticosteroid-cyclophosphamide (CTX) regimens have similar effects on primary membranous nephropathy (PMN). However, no studies have compared RTX with an intravenous CTX regimen, which is more commonly used in China and requires fewer cumulative CTX doses.

Methods

We prospectively assigned 141 PMN patients with baseline proteinuria ≥4 g/24 h, serum albumin <30 g/L, and eGFR ≥30 mL/min × 1.73 m² despite at least 3 months of treatment with ACEI and/or ARB to the RTX group (375 mg/m² per injection per week × 4 injections) or to the CTX group (prednisone 0.8 mg/kg/day and intravenous CTX 500 mg/m² per month until the total dose reached 6-8 g). The primary endpoint was

SUBMITTER: Hu X 

PROVIDER: S-EPMC11488835 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature