Intrinsic dynamics of randomly clustered networks generate place fields and preplay of novel environments.

ABSTRACT: During both sleep and awake immobility, hippocampal place cells reactivate time-compressed versions of sequences representing recently experienced trajectories in a phenomenon known as replay. Intriguingly, spontaneous sequences can also correspond to forthcoming trajectories in novel environments experienced later, in a phenomenon known as preplay. Here, we present a model showing that sequences of spikes correlated with the place fields underlying spatial trajectories in both previously experienced and future novel environments can arise spontaneously in neural circuits with random, clustered connectivity rather than pre-configured spatial maps. Moreover, the realistic place fields themselves arise in the circuit from minimal, landmark-based inputs. We find that preplay quality depends o

SUBMITTER: Breffle J 

PROVIDER: S-EPMC11488848 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature