A neurotransmitter atlas of <i>C. elegans</i> males and hermaphrodites.

ABSTRACT: Mapping neurotransmitter identities to neurons is key to understanding information flow in a nervous system. It also provides valuable entry points for studying the development and plasticity of neuronal identity features. In the Caenorhabditis elegans nervous system, neurotransmitter identities have been largely assigned by expression pattern analysis of neurotransmitter pathway genes that encode neurotransmitter biosynthetic enzymes or transporters. However, many of these assignments have relied on multicopy reporter transgenes that may lack relevant cis-regulatory information and therefore may not provide an accurate picture of neurotransmitter usage. We analyzed the expression patterns of 16 CRISPR/Cas9-engineered knock-in reporter strains for all main types of neurotrans

SUBMITTER: Wang C 

PROVIDER: S-EPMC11488851 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature