Human umbilical cord mesenchymal stem cells on treating osteoarthritis in a rabbit model: Injection strategies.

ABSTRACT: Human umbilical cord mesenchymal stem cells (UCMSCs) are a novel stem-cell source to treat osteoarthritis (OA). Here we investigated the therapeutic effects of UCMSCs injection strategies on knee OA in a rabbit model. Thirty OA rabbits randomly received normal saline, a single dose of 1 × 10⁶ UCMSCs, or three injections of 1 × 10⁶ UCMSCs at 2, 4, 6 weeks. Articular cartilages were collected after 8 weeks. Macroscopic and histological assessments indicated that intra-articular injection of UCMSCs, both single and multiple injection, significantly reduced the formation of periarticular osteophytes and articular cartilage degeneration when compared with the control. Furthermore, both UCMSCs injections increased the expression of chondrogenic markers in the articular cart

SUBMITTER: Deng Z 

PROVIDER: S-EPMC11489144 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature