Analysis of T follicular and T peripheral helper lymphocytes in autoimmune thyroid disease.

ABSTRACT:

Purpose

Peripheral helper T (Tph) cells have an important role in the induction of humoral immune responses and autoantibody production. Accordingly, it is feasible that this lymphocyte subset has a relevant role in the pathogenesis of autoimmune thyroid diseases (AITD). In this study we aim to analyze the levels and function of Tph cells in blood samples from patients with AITD.

Methods

We performed an observational study with cases and controls. Blood samples were obtained from nineteen patients with Hashimoto's thyroiditis (HT), twenty-four with Graves' disease (GD), and fifteen healthy controls. In addition, the levels of follicular T helper (Tfh) cells and Tph cells, the release of interleukin-21 (IL-21) by these lymphocytes and the number of plasmablasts were analyzed

SUBMITTER: Sanchez-Gutierrez R 

PROVIDER: S-EPMC11489195 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature