Temporal evolution of microstructural integrity in cerebellar peduncles in Parkinson's disease: Stage-specific patterns and dopaminergic correlates.

ABSTRACT:

Background

Previous research revealed differences in cerebellar white matter integrity by disease stages, indicating a compensatory role in Parkinson's disease (PD). However, the temporal evolution of cerebellar white matter microstructure in patients with PD (PwPD) remains unclear.

Objective

To unravel temporal evolution of cerebellar white matter and its dopaminergic correlates in PD.

Methods

We recruited 124 PwPD from the PPMI study. The participants were divided into two subsets: Subset 1 (n = 41) had three MRI scans (baseline, 2 years, and 4 years), and Subset 2 (n = 106) had at least two MRI scans at baseline, 1 year, and/or 2 years. Free water-corrected diffusion metrics were used to measure the microstructural integrity in cerebellar peduncles (CP), the main w

SUBMITTER: He C 

PROVIDER: S-EPMC11489329 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature