Application of large-scale and multicohort plasma proteomics data to discover novel causal proteins in gastric cancer.

ABSTRACT:

Purposes

Gastric cancer (GC) is one of the most common malignant tumors threatening human beings and has a poor prognosis. Therefore, exploring unveiled biomarkers or therapeutic targets for the diagnosis and treatment of GC is crucial.

Methods

A total of 5772 protein quantitative trait loci (pQTL) were aggregated from four latest large-scale proteomics cohorts. Two-sample Mendelian randomization (two-sample MR) was utilized to identify the causal effect of blood plasma proteins on GC. Heterogeneity, pleiotropy, and directionality analyses were employed to evaluate proteins identified via two-sample MR. The robustness of results was further validated via colocalization. The drug targets of proteins were evaluated to reveal the compounds that can interfere with these proteins

SUBMITTER: Tang W 

PROVIDER: S-EPMC11489397 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature