Insights into the molecular characteristics of embryonic cranial neural crest cells and their derived mesenchymal cell pools.

ABSTRACT: Neural crest cells (NCCs) are central to vertebrate embryonic development, giving rise to diverse cell types with unique migratory and differentiation capacities. This study examines the molecular characteristics of cranial neural crest cell (CNCC)-derived mesenchymal cells, specifically those from teeth which in deer show continuous but limited growth, and antlers, which exhibit remarkable regenerative capabilities. Here, through single-cell RNA sequencing analysis, we uncover shared gene expression profiles between adult antlerogenic and dental mesenchymal cells, indicating common developmental pathways. We identify a striking resemblance in transcriptomic features between antlerogenic progenitor cells and dental pulp mesenchymal cells. Comparative analysis of CNCC-derived and non-CNCC-d

SUBMITTER: Ba H 

PROVIDER: S-EPMC11489408 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature